Importance of Coordination Chemistry and Role of Sulfonamide Derived Compounds in Biological Activity – A Review

Abstract

Coordination compounds have an important role in our daily life due to their complex structures and magnetic properties. In coordination chemistry we mostly discuss the Schiff bases which are prepared through condensation process between the amine group and an aldehyde (RCH=O) or ketone (R₂C=O) group. These compounds possess many sites to coordinate with the metal atoms that enhanced their bioactivity. Aromatic Schiff bases are pharmaceutically more important. Metal-based Schiff base compounds have become more popular for treating illnesses that are hard to treat with traditional methods. Pharmaceutical researchers took use of unique characteristics of metal chelates as an intermediary between organic and inorganic molecules. (Synthesized, published, and evaluated in the past 10 years) that exhibit antiviral, antimicrobial, antioxidant, and other biological properties such as antitumor and anthelmintic.